Autonomic Innervation from the Aortic Root Ventricular Ganglionated Plexi to the Pulmonary Vein: A Novel Pathway
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Abstract
Background: Autonomic nerve innervation pathway from the ventricular GP to the pulmonary veins (PV) remains unclear.
Aim:This study investigates the autonomic innervations from aortic root ventricular GP to the PVs. Nissl's staining and fluorescent dual label staining were performed to determine the neuron structure in the aortic root GP in five dogs. Avidin Biotin Complex (ABC) staining were performed to study the efferent autonomic pathway from the aortic root GP to the PVs.
Results:Adrenergic and cholinergic neurons were both present in the aortic root GP, with the majorities were cholinergic. ABC positive nerve fibers that contained both cholinergic and adrenergic neurotransmitters penetrated directly from the aortic root GP to the left PVs.
Conclusion: Autonomic innervation of the Left PVs is partly originated from the aortic root ventricular GP.
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Ardell JL (1994) Structure and function of mammalian intrinsic cardiac neurons. In: Armour JA and Ardell JL, eds. Neurocardiology. Oxford Univ. Press:New York 95-114.
Pauza DH, SkripkaV, Pauziene N, Stropus R (2000) Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart. Anat Rec 259: 353-382.
Vaitkevicius R, Saburkina I, Zaliunas R, Pauziene N, Vaitkeviciene I, et al. (2008) Innervation of pulmonary veins: morphologic pattern and pathways of nerves in the human fetus. Ann Anat 190: 158-166.
James TN (2004) Combinatorial roles of the human intertruncal plexus in mediating both afferent and efferent autonomic neural traffic and producing a cardiogenic hypertensive chemoreflex. Progress in Cardiovascular Diseases 46: 539-572.
Butler CK, Smith FM, Cardinal R, Murphy DA, Hopkins DA, et al. (1990) Cardiac responses to electrical stimulation of discrete loci in canine atrial and ventricular ganglionted plexi. Am J Physiol 259: H1365-HJ1373.
Hong-Tao Wang, Qiang-Sun Zheng, Xiong-Tao Liu, Jun Li, Fu-Jun Shang, et al. (2012) Non-Isolation Treatment of Atrial Fibrillation: Does Autonomic Nerve Modulation Really Act? In Jong-Il Choip,eds: Atrial Fibrillation - Basic Research and Clinical Applications. Rijeka, Croatia, InTech 255-266.
Po SS, Nakagawa H, Jackman WM (2009) Localization of left atrial ganglionated plexi in patients with atrial fibrillation.J Cardiovasc Electrophysiol 20: 1186-1189.
Hou Y, Scherlag BJ, Lin J, Zhang Y, Lu Z, et al. (2007) Ganglionated plexi modulate extrinsic cardiac autonomic nerve input:Effects on sinus rate, atrioventricular conduction, refractoriness, and inducibility of atrial fibrillation. J Am Coll Cardiol 50: 61-68.
Lu Z, Scherlag BJ, Lin J, Niu G, Fung KM, et al. (2008) Atrial fibrillation begets atrial fibrillation: Autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing. Circ Arrhythm Electrophysiol 1: 184-192.
Tan AY, Chen PS, Chen LS, Fishbein MC (2007) Autonomic nerves in pulmonary veins. Heart Rhythm 4: S57-60.
Noheria A, Patel SM, Mirzoyev S, Madhavan M, Friedman PA, et al. (2013) Decreased postoperative atrial fibrillation following cardiac transplantation: the significance of autonomic denervation. Pacing Clin Electrophysiol 36: 741-747.
Kuo JY, Chen SA (2007) Is vagal denervation a good alternative or just adjunctive to pulmonary vein isolation in catheter ablation of atrial fibrillation? J Am Coll Cardiol 49: 1349-1351.
Vaitkevicius R, Saburkina I, Rysevaite K, Vaitkeviciene I, Pauziene N, et al. (2009) Nerve supply of the human pulmonary veins: an anatomical study. Heart Rhythm 6: 221-228.
Pauza DH, Skripka V, Pauziene N (2002) Morphology of the intrinsic cardiac nervous system in the dog: a whole-mount study employing histochemical staining with acetylcholinesterase. Cells Tissues Organs 172: 297-320.
He B, Lu Z, He W, Huang B, Yu L, et al. (2013) The effects of atrial ganglionated plexi stimulation on ventricular electrophysiology in a normal canine heart. J Interv Card Electrophysiol 37: 1-8.
He B, Lu Z, He W, Wu L, Cui B, et al. (2013) Effects of ganglionated plexi ablation on ventricular electrophysiological properties in normal hearts and after acute myocardial ischemia. Int J Cardiol 168: 86-93.
De Simone CV, Madhavan M, Venkatachalam KL, Knudson MB, Asirvatham SJ (2013) Percutaneous autonomic neural modulation: a novel technique to treat cardiac arrhythmia. Cardiovasc Revasc Med 14: 144-148.
Zhou J, Scherlag BJ, Edwards J, Jackman WM, Lazzara R, et al. (2007) Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi. J Cardiovasc Electrophysiol 18: 83-90 .