Nature of Human Gut Microbiome: How do they play in Cardiovascular Disease?
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Abstract
Cardiovascular disease is the number one killer of death around the world. Most of the cardiovascular diseases are caused by sedentary life style, bad eating habit, tobacco smoking, high alcohol intake, dyslipidemia and genetic factors .Recently the idea of human microbiome science has emerged in diseases pathogenesis .The human gut is a house of trillions of microbial floral. Since a couple of decades ago, there has been interesting insights into the human gut microbiota and have highlighted its increasingly association to cardiovascular (CV) and metabolic diseases. Trimethylamine N-oxide (TMAO), which is a metabolic product from gut microbiota plays a central role in cardiovascular disease pathogenesis. Nature of microbial inhabitants within the host has been noticed by the numbers of scientists and researchers to understand more about the hidden mechanism of diseases pathogenesis including cardiovascular disease, metabolic and autoimmune diseases and it has become a good hope to develop new drug designs to prevent metabolic and cardiovascular disease in near future.
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Ursell LK, Metcalf JL, Parfrey LW, Knight R (2012) Defining the human microbiome. Nutr Rev 70: 38-44. Link: https://goo.gl/3DKvGA
Ana M Valdeand (2018) Role of the gut microbiota in nutrition and health BMJ 2018; 361. Link: https://goo.gl/FDAtCB
Janssens Y, Antoon Bronselaer JN, Debunne N (2018) Disbiome database: linking the microbiome to disease BMC Microbiology 18: 50. Link: https://goo.gl/GnHFrG
Tang WH, Hazen SL (2014) The contributory role of gut microbiota in cardiovascular disease. J Clin Invest 124: 4204-11. Link: https://goo.gl/bqt599
Liang D, Ka-Kit Leung R, Guan W, Au WW (2018) Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities J of Gut Pathogen. Link: https://goo.gl/c3552C
Wilson Tang WH, Kitai T, Hazen SL (2017) Gut Microbiota in Cardiovascular Health and Disease, Circulation Research 120:1183–1196. Link: https://goo.gl/eJdQrD
Trøseid M, Ueland T, Hov JR, Svardal A, Gregersen I, et al. (2015) Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. J Intern Med 277: 717-26. Link: https://goo.gl/uXHKc1
Romano KA, Vivas EI, Amador-Noguez D, Rey FE, (2015) Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio 6: e02481. Link: https://goo.gl/BJ36yE
Kim Y, Keogh J, Clifton PA (2015) review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus. Metabolism 64: 768-79. Link: https://goo.gl/Un8rVT
Baohon gWang, Mingfei Yao (2017) The Human Microbiota in Health and Disease, Microecology 71-82.
Baker JR, Chaykin S (1962) "The biosynthesis of trimethylamine-N-oxide". J. Biol. Chem 237: 1309–1313. Link: https://goo.gl/xazn6F
Wang Z, Klipfell E, Bennett BJ (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472: 57-63. Link: https://goo.gl/nAw1DV
Zhu W, Gregory JC, Org E (2016) Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165: 111–124. Link: https://goo.gl/4UcamN
Dambrova M, Latkovskis G (2016) Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels. xp Clin Endocrinol Diabetes 124: 251-6. Link: https://goo.gl/Gx4j1J
Heianza Y, Wenjie Ma (2017) Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies. Journal of the American Heart Association 6: e004947. Link: https://goo.gl/vZ5srD
Roberts AB (2018) Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential, Nature Medicine. Link: https://goo.gl/kaNXkt