FMTVDM-Finally Opens the Doorway from Qualitative to Quantitative Measurement and Treatment of Heart Disease

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Richard M Fleming*
Matthew R Fleming

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Fleming, R. M., & Fleming, M. R. (2020). FMTVDM-Finally Opens the Doorway from Qualitative to Quantitative Measurement and Treatment of Heart Disease. Journal of Cardiovascular Medicine and Cardiology, 7(2), 060–062. https://doi.org/10.17352/2455-2976.000114
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Fleming RM, Fleming MR, McKusick A, Chaudhuri TK, Dooley WC, et al. (2018) FMTVDM©℗ stress-first/stress-only imaging is here! But first we need to clarify the use of what (1) Stress, (2) rest, (3) redistribution and (4) quantification, really mean. J Nucl Med Radiat Ther 9. Link: https://bit.ly/2JSBaiW

Fleming RM, Fleming MR, McKusick A, Chaudhuri TK (2018) Semi-quantification limitations: FMTVDM©℗ demonstrates quantified tumor response to treatment with both regional blood flow and metabolic changes. J Nucl Med 59: 1643-1644. Link: https://bit.ly/34zMVVa

Fleming RM, Fleming MR, McKusick A, Chaudhuri TK (2018) FMTVDM©℗ Nuclear Imaging Artificial (AI) Intelligence but first we need to clarify the use of (1) Stress, (2) Rest, (3) Redistribution and (4) Quantification. Biomed J Sci and Tech Res 7: 1-4. Link: https://bit.ly/3c8xsOd

Fleming RM, Fleming MR, McKusick A, Chaudhuri TK (2018) Virtual quantification is not True quantification. FMTVDM-TFM©℗ Provides True quantification for SPECT and PET. Arch Med 10: 1-3. Link: https://bit.ly/3bcwpwV

Fleming RM (2018) FMTVDM©℗ Provides the First True SPECT and PET Quantification and Not Virtual Guesstimation Produced by SUV and Extraction Fraction, Yielding First Accurate Theranostic Method. J Nucl Med Radiat Ther 9: e118. Link: https://bit.ly/3edi6Kb

Fleming RM, Fleming MR, Dooley WC, McKusick A, Chaudhuri T (2018) FMTVDM©℗ Provides the First Nuclear Quantitative Method for Nuclear Cardiology and Introduces a New Era for Nuclear Cardiology. J Nucl Card 25: 1453.

Fleming RM, Fleming MR, Chaudhuri TK, McKusick A (2019) FMTVDM©℗ Provides the First Patented Quantification of Myocardial Perfusion Imaging (MPI) Yielding Theranostic Benefit for Individuals with Suspected Coronary Artery Disease (CAD). Biomed J Sci Tech Res 13. Link: https://bit.ly/3ccVOqj

Fleming RM, Fleming MR, Chaudhuri TK, Andrew M (2019) FMTVDM provides first patented Quantitative Method to accurately Measure both Heart Disease and Breast Cancer on the “Health-Spectrum”. J Cardiovasc Med Cardiol 6: 019-020. Link: https://bit.ly/3eiTC2r

Fleming RM, Fleming MR (2019) The Importance of Thinking about and Quantifying Disease like Cancer and Heart Disease on a “Health-Spectrum” Continuum. J Compr Cancer Rep 3: 1-3. Link: https://bit.ly/2ViENnM

Fleming RM, Fleming MR, Chaudhuri TK (2019) True AI Implementation Through FMTVDM Proprietary Equations and QCA. Biomed J Sci Tech Res 20: 15154-15160. Link: https://bit.ly/2y1GCxj

Fleming RM, Fleming MR, Chaudhuri TK, McKusick A, Dooley WC (2019) Nuclear Imaging: Physician Confusion Over True Quantification and Isotope Redistribution. J Clin Cases Rep 3: 32-42. Link: https://bit.ly/2yShF82

Fleming RM, Fleming MR, Chaudhuri TK (2019) The Need to Actually Measure What We’re Talking about before We Put it All Together. Int J Nuclear Med Radioactive Subs 2: 000114.

Sheikh A (2018) Evolution of Quantification in Clinical Nuclear Medicine: A Brief Overview of Salient Uses and Upcoming Trends. J Nucl Med Radiat Ther 9: 375. Link: https://bit.ly/2VjC2m1

Fleming RM, Fleming MR, Dooley WC, Chaudhuri TK (2020) Invited Editorial. The Importance of Differentiating Between Qualitative, Semi-Quantitative and Quantitative Imaging – Close Only Counts in Horseshoes. Eur J Nucl Med Mol Imaging 47: 753-755. Link: https://bit.ly/2RuaPMx

Fleming RM (2000) Shortcomings of coronary angiography. Letter to the Editor. Cleve Clin J Med 67: 450-451. Link: https://bit.ly/34t6jmw

Fleming RM (2001) Coronary Artery Disease is More than Just Coronary Lumen Disease. Amer J Card 88: 599-600. Link: https://bit.ly/2ySGIb1

Fleming RM, Kirkeeide RL, Smalling RW, Gould KL (1991) Patterns in Visual Interpretation of Coronary Arteriograms as Detected by Quantitative Coronary Arteriography. J Am Coll Cardiol 18: 945-951. Link: https://bit.ly/3efiyHJ

Fleming RM, Fleming DM, Gaede R (1996) Teaching Physicians and Health Care Providers to Accurately Read Coronary Arteriograms. Angiology 47: 349-359. Link: https://bit.ly/3caEm5H

The Fleming Method for Tissue and Vascular Differentiation and Metabolism (FMTVDM) using same state single or sequential quantification comparisons. Patent Number 9566037.

Fleming RM, Harrington GM, Baqir R, Jay S, Challapalli S, et al. (2009) The Evolution of Nuclear Cardiology takes Us Back to the Beginning to Develop Today’s “New Standard of Care” for Cardiac Imaging: How quantifying regional radioactive counts at five and 60 minutes post-stress unmasks hidden ischemia. Methodist Debakey Cardiovasc J 5: 42-48. Link: https://bit.ly/34umwrS

(2009) Quantifying Regional Radioactive Counts at 5 and 60 Minutes Post-Stress Unmasks Hidden Ischemia. Methodist DeBakey Cardiovascular Journal (MDCVJ) 5: 42-48.

Fleming RM, Harrington GM (2010) FHRWW stress SPECT protocol reduces radioactive dosage and increases ischemia detection. ANZ Nuclear Medicine 41: 24-32. Link: https://bit.ly/2V0IMqc

Fleming RM, Harrington GM, Baqir R, Jay S, Challapalli S, et al. (2011) Renewed Application of an Old Method Improves Detection of Coronary Ischemia. A Higher Standard of Care. Gamma Gazette 1: 50-58. Link: https://bit.ly/2JT7T7X

Fleming RM, Harrington GM, Jay S, Avery K (2011) FHRWW Rest SPECT Viability Imaging – Cardiac viability measured using resting FHRWW Redistribution of Sestamibi: The Scientific Evidence proves “Sestamibi is not Superglue.” ANZ Nuc Med.

Fleming RM, Harrington GM (2011) Quantitative measurement of sestamibi redistribution to detect hidden ischemia made possible by application of Blumgart’s method. J Nucl Med 52: 1162. Link: https://bit.ly/39Vz1gV

Fleming RM, Harrington GM, Kearney DS, Tomsho M, Sheils J (2012) Myoview and Sestamibi redistribution, stress once – image twice protocol improves detection of ischemia in addition to improving patient throughput and reducing patient radiation to 3.75 mSv. J Nucl Med 53: 1831. Link: https://bit.ly/2y2yxsm

Fleming RM, Fleming MR, Chaudhuri T, McKusick A, Dooley WC et al. (2018) Both percent diameter stenosis (%DS) and coronary flow reserve can be derived directly from myocardial perfusion imaging using FMTVDM and measurement of isotope redistribution. J Nucl Med Radiat Ther 9: 353. Link: https://bit.ly/3eg3bPl

Fleming RM, Fleming MR, Dooley WC, Sheikh A, McKusick A, et al. (2018) FMTVDM – FHRWW & B.E.S.T. The FIRST TRUE “Quantitative” Nuclear Imaging Protocols with Proprietary Equations following The Fleming Method (TFM) for Nuclear Scintillation Equipment Quantitative Standardization. Biomed J Sci Tech Res 4: 1-4. Link: https://bit.ly/34rrIN3

Fleming RM, Fleming MR, McKusick A, Chaudhuri T (2018) FMTVDM-TFM©℗: True Quantification requires Standardization of the tool being used to Measure, with a Known, Unchanging Standard to produce accurate, consistent and reproducible Quantified Measurements. J Nucl Cardiol 26: 1780-1783. Link: https://bit.ly/3aVYQyR

Fleming RM, Fleming MR, Harrington G, McKusick A, Chaudhuri T (2018) USVAH Study demonstrates statistically significant improvement in diagnosis and care of U.S. Veterans using FMTVDM-FHRWW ©℗ “Quantitative” Nuclear Imaging. The era of truly quantitative stress-first, stress-only imaging has begun!. J Nucl Med Radiat Ther S9: 6. Link: https://bit.ly/39XHbW3

Fleming RM, Fleming MR, McKusick A, Chaudhuri T (2018) Multi Center Clinical

Trial Confirms FMTVDM©℗ MPI in Seven Modern Clinical Laboratories in the U.S.A. and Asia. Artificial Intelligence (AI) with True Quantification. J Nucl Med Radiat Ther 9: 372. Link: https://bit.ly/2wwOFSv

Fleming RM, Fleming MR, Chaudhuri TK, McKusick A (2019) Proposed Acute Coronary Syndrome (ACS) Chest Pain Pathway Using Quantitative FMTVDM Nuclear Imaging. Adv Can Res Clinical Imag 1: 1-2. Link: https://bit.ly/3ecqXf3

Fleming RM, Fleming MR, Chaudhuri TK, Dooley WC (2019) Simultaneous Quantitative Cardio Oncology Imaging Now Possible Using FMTVDM. Biomed J Sci Tech Res 20: 15138-15143. Link: https://bit.ly/2ySjQZg

Fleming RM, Fleming MR, Chaudhuri TK, McKusick A (2019) Machine Learning through FMTVDM Proprietary QCA Equations. J Angiol Vasc Surg 4: 026. Link: https://bit.ly/3a0XQYM

Fleming RM, Fleming MR, Chaudhuri TK, McKusick A (2019) First Patented Quantitative Molecular Imaging Method for Detection and Measurement of CAD and Cancer. ACTA Scientific Pharm Sci 3: 30-32. Link: https://bit.ly/2JVo9p1

Fleming RM, Fleming MR, Chaudhuri TK, McKusick A (2019) FMTVDM Quantitative Imaging Replaces Current Qualitative Imaging for Coronary Artery Disease and Cancer, Increasing Diagnostic Accuracy and Providing Patient- Specific, Patient-Directed Treatment. Cardio Open 4: 1-2. Link: https://bit.ly/2XtLMwz

Fleming RM, Fleming MR, Chaudhuri TK, Harrington GM (2019) Redistribution Measurement: A New (Old) Tool for Finding Heart Disease? Acta Scientific Pharm Sci 3: 25-28.

Fleming RM, Fleming MR, Chaudhuri TK, Dooley WC (2019) Part I: Proposed New Standards of Care for the Work up of Chest Pain and Breast Lumps. J Emer Med Prim Care 2: 1-3. Link: https://bit.ly/2RK0XhR

Fleming RM, Fleming MR, Chaudhuri TK, Dooley WC (2019) Part II: Proposed New Standards of Care for the Work up of Chest Pain and Breast Lumps. J Emer Med Prim Care 2: 4-6. Link: https://bit.ly/2V2gbAO

Fleming RM, Fleming MR, Chaudhuri TK (2019) Myocardial Perfusion Imaging Measurements with FMTVDM Unmask Critial CAD. Acta Scientific Pharm Sci 1-2. Link: https://bit.ly/2RuJUQr

Fleming RM, Harrington GM, Baqir R (2008) Using Multiple Images Post-stress to Enhance Diagnostic Accuracy of Myocardial Perfusion Imaging: The Clinical Importance of Determining Washin & Washout Indicates a Parabolic Function Between Coronary Perfusion (Blood Flow) and Cellular (“Uptake/Release) Function. (submitted by “invitation only” to Nova Science March 2008, Heart Disease in Men.

Fleming RM, Harrington GM, Baqir R (2009) Heart Disease in Men. Chapter 3. Using Multiple Images Post-Stress to Enhance diagnostic Accuracy of Myocardial Perfusion Imaging: The Clinical Importance of Determining Washin and Washout Indicates a Parabolic Function between Coronary Perfusion (Blood Flow) and Cellular ("Uptake/Release") Function. Alice B. Todd and Margo H. Mosley Editors, Nova Publishers 75-100. Link: https://bit.ly/34q3jYc

Fleming RM, Harrington GM (2011) Chapter 13. Fleming Harrington Redistribution Wash-in Washout (FHRWW): The Platinum Standard for Nuclear Cardiology. Establishing Better Standards of Care in Doppler Echocardiography, Computed Tomography and Nuclear Cardiology. Richard M. Fleming, Editor, Intech Publishing. Link: https://bit.ly/2Rx6DeW

(2019) FMTVDM: The Fleming Method for Tissue and Vascular Differentiation and Metabolism Using Same State Single or Sequential Quantification Comparisons. Evidence Based Medicine. Link: https://bit.ly/3b2eUPw